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Bioprocessing / Single-Use Bioreactor System

BIOne

Single-Use Bioreactor System

Convert your existing benchtop glass bioreactor to a single-use bioreactor in seconds! Distek, Inc. has developed a benchtop scale single-use bioreactor (SUB) for mammalian cell growth, cell therapy, insect cells, and other unique applications performed in a stirred tank bioreactor. The gamma irradiated BIOne SUB is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a disposable SUB within a matter of seconds. Upon media addition, the liner expands and molds to the glass vessel, preserving the geometry of the existing bioreactor. The BIOne SUB’s liner material emulates the large-scale SUBs used in pilot and commercial biopharm production facilities around the world. Performing R & D studies using the most similar material on the market streamlines your tech transfer and can de-risk your process BEFORE transferring to pilot scale.

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Convert Your Glass Vessel to Single-Use in Seconds

The pre-sterilized BIOne system is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a sterile, disposable SUB within a matter of seconds.

2L & 5L Working Volume
Weldable Tubing
USP Class VI Materials
Compatible with Most Manufacturers’ Glass Vessels and Controllers

Multiple Sensor Ports

The single-use headplate contains all of the components of your existing glass system as well as four probe ports including:

Non-invasive DO sensor port
Non-invasive pH sensor port
Two universal sensor ports which can be utilized for 12mm, CO₂, DO, pH, biomass, glucose, etc.

BIOne Liner Material

The low antioxidant bioprocess film used is comprised of 3 layers, each serving a specific function:

Outer Layer (LDPE) – Mechanical Strength
Middle Barrier Layer (EVOH) – Gas Barrier
Contact Layer (ULDPE) – Cell Culture Compatible, Biologically Inert

Convert Your Glass Vessel to Single-Use in Seconds

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Applications

Advancing the Robust Manufacture of T-Cell Therapies through the Application of Stirred Tank Bioreactors

Stirred-tank bioreactors present an option for the expansion of primary human T-Cells that has previously not been pursued due to concerns about shear stress. Small scale studies have shown that impeller driven mixing stirred-tank bioreactors do not increase cell death or limit expansion potential. Translating the learnings from those small scale studies to the autologous manufacturing scale has shown that the BIOne stirred-tank bioreactor produces a consistent culture environment and high cell yields. The BIOne significantly outperformed rocking bioreactor systems in both total yield and production efficiency. Click HERE to view the Poster.

BIOne White Paper

The BIOne Benchtop Single-Use Bioreactor System For Mammalian Cell Growth And Recombinant Protein Production As A Robust Model For Bioprocess Development. Click HERE to view the white paper.

BIOne Poster

Distek, Inc. has developed a benchtop scale single-use bioreactor (SUB) system for mammalian cell growth and recombinant protein production. The pre-sterilized BIOne system is engineered with a disposable headplate welded to a triple-layered liner that can be easily inserted into a non-sterile bioreactor glass vessel, converting it to a sterile, disposable SUB within a matter of seconds. Click HERE to view the poster.

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Request a Quote

Distek provides quotations on price and availability upon request. Quotations are processed by our Inside Sales Team 5 days a week from 8:30 to 5:00 EST. Typical turnaround for all quotes is 24-48 hours. Should you have any questions please direct them to orders@distekinc.com.

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Need Assistance?

Service and support from Distek is unparalleled in the industry. With over 40 years of experience, Distek is well-qualified to meet the unique challenges of your laboratory. Click the link below to request support.

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