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Pharmaceutical Dissolution Testing / UV Fiber Optic Dissolution

Opt-Diss 410

In-Situ Fiber Optic UV System for Dissolution Testing

No more sampling! The Distek Opt-Diss 410 in-situ fiber optic UV system measures directly in the vessel, eliminating the need for conventional sampling, and with-it consumables like filters, tubing and syringes, saving time, labor, and money. Moving light rather than liquids also allows generating near real-time dissolution data and nearly limitless sample points as frequently as every five seconds.

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Simple & Efficient Dissolution Testing

Truly automated data collection and analysis means start of test to a complete report only takes as long as the test itself, with no operator interaction required. And collecting data as fast as every 5 seconds is no more effort.

Multicomponent Analysis

Measure two components in the same dissolution test without the need for LC, including products with two APIs or interaction with excipients, coatings, capsules, or any other source of deviation of the UV spectra.

In-Situ Measurements

Keeping the science in the vessel! The Opt-Diss 410 measures directly in the vessel, eliminating manual or automated sampling along with the associated consumables, labor and off-line analysis.

Choose from patented ARCH probes designed specifically for dissolution testing with negligible hydrodynamic effect
Or conventional dip probes with fixed or interchangeable pathlengths

Opt-Diss 410

Opt-Diss 410 Arch Probes

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Opt-Diss 410 with Model 2500 Select

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Opt-Diss 410 Dip Probes

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Opt-Diss 410 with symphony 7100

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Opt-Diss 410 Arch Probe Spacers

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Opt-Diss 410 with Model 2500 RTD

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Applications

Analysis of Two Active Pharmaceutical Ingredients (API) Products Using UV Spectrophotometry with Multi-Component Analysis and a Fiber Optic Dissolution Analyzer

This white paper explains the theory behind the MCA algorithm methodology. Then, used in tandem with in-situ fiber optics, the accuracy of the technique is demonstrated by recovering the concentration of two APIs in known mixed solutions. Finally, an example is given of accurately monitoring and quantifying the dissolution profile of an actual commercial product containing two APIs, demonstrating the elimination of the need to draw samples or to perform HPLC analysis for many of these type of products. CLICK HERE TO VIEW THE WHITE PAPER.

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Request a Quote

Distek provides quotations on price and availability upon request. Quotations are processed by our Inside Sales Team 5 days a week from 8:30 to 5:00 EST. Typical turnaround for all quotes is 24-48 hours. Should you have any questions please direct them to orders@distekinc.com.

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Need Assistance?

Service and support from Distek is unparalleled in the industry. With over 45 years of experience, Distek is well-qualified to meet the unique challenges of your laboratory. Click the link below to request support.

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Bioreactors

Opt-Diss 410

In-Situ Fiber Optic UV System for Dissolution Testing

Simple & Efficient Dissolution Testing

Multicomponent Analysis